Abstract

Frequency-domain diffuse optical spectroscopy (FD-DOS) is an established technique capable of determining optical properties and chromophore concentrations in biological tissue. Most FD-DOS systems use either manually positioned, handheld probes or complex arrays of source and detector fibers to acquire data from many tissue locations, allowing for the generation of 2D or 3D maps of tissue. Here, we present a new method to rapidly acquire a wide range of source–detector (SD) separations by mechanically scanning a single SD pair. The source and detector fibers are mounted on a scan head that traces a hypotrochoidal pattern over the sample that, when coupled with a high-speed FD-DOS system, enables the rapid collection of dozens of SD separations for depth-resolved imaging. We demonstrate that this system has an average error of $4\pm 2.6\%$ in absorption and $2\pm 1.8\%$ in scattering across all SD separations. Additionally, by linearly translating the device, the size and location of an absorbing inhomogeneity can be determined through the generation of B-scan images in a manner conceptually analogous to ultrasound imaging. This work demonstrates the potential of single optode diffuse optical scanning for depth resolved visualization of heterogeneous biological tissues at near real-time rates.

© 2018 Optical Society of America

Next-generation frequency domain diffuse optical imaging systems using silicon photomultipliers

Vincent J. Kitsmiller and Thomas D. O’Sullivan
Opt. Lett. 44(3) 562-565 (2019)

Effect and correction of optode coupling errors in breast imaging using diffuse optical tomography

Shuying Li, Kexin Huang, Menghao Zhang, K. M. Shihab Uddin, and Quing Zhu
Biomed. Opt. Express 12(2) 689-704 (2021)

Multiple-view diffuse optical tomography system based on time-domain compressive measurements

Andrea Farina, Marta Betcke, Laura di Sieno, Andrea Bassi, Nicolas Ducros, Antonio Pifferi, Gianluca Valentini, Simon Arridge, and Cosimo D’Andrea
Opt. Lett. 42(14) 2822-2825 (2017)

In vivo time-gated diffuse correlation spectroscopy at quasi-null source-detector separation

M. Pagliazzi, S. Konugolu Venkata Sekar, L. Di Sieno, L. Colombo, T. Durduran, D. Contini, A. Torricelli, A. Pifferi, and A. Dalla Mora
Opt. Lett. 43(11) 2450-2453 (2018)

Time domain diffuse Raman spectrometer based on a TCSPC camera for the depth analysis of diffusive media

S. Konugolu Venkata Sekar, S. Mosca, S. Tannert, G. Valentini, F. Martelli, T. Binzoni, Y. Prokazov, E. Turbin, W. Zuschratter, R. Erdmann, and A. Pifferi
Opt. Lett. 43(9) 2134-2137 (2018)