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In vivo imaging of the depth-resolved optic axis of birefringence in human skin

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Abstract

Recent progress has enabled the reconstruction of the local (i.e., depth-resolved) optic axis (OAx) of biological tissue from measurements made with polarization-sensitive optical coherence tomography (PS-OCT). Here we demonstrate local OAx imaging in healthy human skin in vivo. The images reveal dense, weaving patterns that are imperceptible in OCT intensity tomograms or conventional PS-OCT metrics and that suggest a mesh-like tissue organization, consistent with the morphology of dermal collagen. Using co-registered polarization-sensitive optical coherence microscopy, we furthermore investigated the impact of spatial resolution on the recovered OAx patterns and confirmed their consistency. OAx orientation as a contrast mechanism merits further exploration for applications in dermatology.

© 2020 Optical Society of America

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Supplementary Material (6)

NameDescription
Visualization 1       Fly-through of the volumetric imaging (10 × 10 × 1.35 mm, x × y × z) of the back of a healthy adult volunteer’s hand, measured with PS-OCT in vivo and visualized in flattened cross-sectional B-scan view.
Visualization 2       Fly-through of the volumetric imaging (10 × 10 × 1.35 mm, x × y × z) of the back of a healthy adult volunteer’s hand, measured with PS-OCT in vivo and visualized in flattened en-face view.
Visualization 3       Fly-through of the volumetric imaging (5 × 5 × 0.93 mm, x × y × z) of the volar (top) and dorsal (bottom) forearm of a healthy adult, measured with PS-OCT in vivo and visualized in flattened cross-sectional B-scan view.
Visualization 4       Fly-through of the volumetric imaging (5 × 5 × 0.93 mm, x × y × z) of the volar (top) and dorsal (bottom) forearm of a healthy adult, measured with PS-OCT in vivo and visualized in flattened en-face view.
Visualization 5       Fly-through of the volumetric imaging (1 × 1 × 0.50 mm, x × y × z) of the back of a healthy adult volunteer’s hand, measured with PS-OCM in vivo and visualized in flattened cross-sectional B-scan view.
Visualization 6       Fly-through of the volumetric imaging (1 × 1 × 0.50 mm, x × y × z) of the back of a healthy adult volunteer’s hand, measured with PS-OCM in vivo and visualized in flattened en-face view.

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Figures (3)

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