Abstract

Microsphere biolasers have attracted a great deal of interest due to their potential for biosensing and cell tracking. Here we demonstrate a novel, to the best of our knowledge, microfluidic-based fabrication of nearly monodisperse dye-doped protein microsphere biolasers with a tunable size from 150 to 50 µm. In particular, for an 85 µm-bead, about 70% of the fabricated microspheres have the same size of 85 µm. Under optical pumping, the fabricated microspheres emit whispering gallery mode lasing emission with a lasing threshold of ${{7}}\;\unicode{x00B5} {\rm{J}}\;{{\rm{mm}}^{- 2}}$ and quality ($\!Q$) factor up to 3000. Interestingly, microspheres with the same size exhibit a similar lasing threshold and spectrum. The result indicates a high reproducibility of microsphere biolasers by the microfluidic-based fabrication technique. This Letter provides an effective method for mass production of high-$Q$ factor microsphere biolasers which is a significant step toward real biosensing and medical applications.

© 2021 Optical Society of America

2 µm lasing from Tm³⁺-doped PbO-PbF₂-Bi₂O₃-Ga₂O₃ glass microspheres

Jin Yu, Yanqiu Du, Xiaotong Zhao, Shijie Jia, Zhenrui Li, Shunbin Wang, and Pengfei Wang
Opt. Lett. 46(20) 5084-5087 (2021)

High-quality high-throughput silicon laser milling using a 1 kW sub-picosecond laser

Daniel Holder, Rudolf Weber, Christoph Röcker, Gerhard Kunz, David Bruneel, Martin Delaigue, Thomas Graf, and Marwan Abdou Ahmed
Opt. Lett. 46(2) 384-387 (2021)

Low-loss and high-resolution mechanical mode tuning in microspheres

Jing-yu Liang, Min Wang, Dong Ruan, and Gui-Lu Long
Opt. Lett. 46(7) 1592-1595 (2021)

Fundamental limit of microresonator field uniformity and slow light enabled ultraprecise displacement metrology

M. Sumetsky
Opt. Lett. 46(7) 1656-1659 (2021)

Bio-inspired wrinkle microstructures for random lasing governed by surface roughness

Venkata Siva Gummaluri, R. Gayathri, C. Vijayan, and Murukeshan Vadakke Matham
Opt. Lett. 46(5) 1033-1036 (2021)