High-sensitivity frequency modulation CARS with a compact and fast tunable fiber-based light source

Thomas Würthwein; Maximilian Brinkmann; Tim Hellwig; Kristin Wallmeier; Carsten Fallnich; Carsten Fallnich; Carsten Fallnich

doi:10.1364/OL.425578

Optics Letters
Vol. 46,
Issue 15,
pp. 3544-3547
(2021)
•https://doi.org/10.1364/OL.425578

High-sensitivity frequency modulation CARS with a compact and fast tunable fiber-based light source

Thomas Würthwein, Maximilian Brinkmann, Tim Hellwig, Kristin Wallmeier, and Carsten Fallnich

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Thomas Würthwein, Maximilian Brinkmann, Tim Hellwig, Kristin Wallmeier, and Carsten Fallnich, "High-sensitivity frequency modulation CARS with a compact and fast tunable fiber-based light source," Opt. Lett. 46, 3544-3547 (2021)

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- Microscopy
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About this Article
History
- Original Manuscript: March 30, 2021
- Revised Manuscript: June 16, 2021
- Manuscript Accepted: June 16, 2021
- Published: July 21, 2021

Abstract

Frequency modulation (FM) coherent anti-Stokes Raman scattering (CARS) is presented, using a compact as well as fast and widely tunable fiber-based light source. With this light source, Raman resonances between $700\;{{\rm cm}^{- 1}}$ and $3200\;{{\rm cm}^{- 1}}$ can be addressed via wavelength tuning within only 5 ms, which allows for FM CARS measurements with frame-to-frame wavelength switching. Moreover, the functionality for high-sensitivity FM CARS measurements was integrated by means of fiber optics to keep a stable and reliable operation. The light source accomplished FM CARS measurements with a 40 times enhanced sensitivity at a lock-in amplifier (LIA) bandwidth of 1 Hz. For fast imaging with frame-to-frame wavelength switching at a LIA bandwidth of 1 MHz, an 18-fold contrast enhancement could be verified, making this light source ideal for routine and out-of-lab FM CARS measurements for medical diagnostics or environmental sensing.

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Supplementary Material (1)

Name	Description
Visualization 1	Real-time imaging of the dDMSO and lipid resonances in fresh adipose tissue with standard and FM CARS at four frames per second (256x256 pixels, no averaging) with frame-to-frame wavelength-switching.

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Data underlying the results presented in this paper are not publicly available at this time but may be obtained from the authors upon reasonable request.

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