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High-sensitivity frequency modulation CARS with a compact and fast tunable fiber-based light source

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Abstract

Frequency modulation (FM) coherent anti-Stokes Raman scattering (CARS) is presented, using a compact as well as fast and widely tunable fiber-based light source. With this light source, Raman resonances between $700\;{{\rm cm}^{- 1}}$ and $3200\;{{\rm cm}^{- 1}}$ can be addressed via wavelength tuning within only 5 ms, which allows for FM CARS measurements with frame-to-frame wavelength switching. Moreover, the functionality for high-sensitivity FM CARS measurements was integrated by means of fiber optics to keep a stable and reliable operation. The light source accomplished FM CARS measurements with a 40 times enhanced sensitivity at a lock-in amplifier (LIA) bandwidth of 1 Hz. For fast imaging with frame-to-frame wavelength switching at a LIA bandwidth of 1 MHz, an 18-fold contrast enhancement could be verified, making this light source ideal for routine and out-of-lab FM CARS measurements for medical diagnostics or environmental sensing.

© 2021 Optical Society of America

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Supplementary Material (1)

NameDescription
Visualization 1       Real-time imaging of the dDMSO and lipid resonances in fresh adipose tissue with standard and FM CARS at four frames per second (256x256 pixels, no averaging) with frame-to-frame wavelength-switching.

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Data underlying the results presented in this paper are not publicly available at this time but may be obtained from the authors upon reasonable request.

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