Abstract

Defocus aberration in optical systems, including optical coherence tomography (OCT) systems employing Gaussian illumination, gives rise to the well-known compromise between transverse resolution and depth-of-field. This results in blurry images when out-of-focus, whilst other low-order aberrations (e.g., astigmatism, coma, etc.) present in both the OCT system and biological samples further reduce image resolution and contrast. Computational adaptive optics (CAO) is a computed optical interferometric imaging technique that modifies the phase of the OCT data in the spatial frequency domain to correct optical aberrations and provide improvement of the image quality throughout the three-dimensional (3D) volume. In this Letter, we report the first implementation of CAO for polarization-sensitive OCT to correct defocus and other low-order aberrations, providing enhanced polarization-sensitive imaging contrast (i.e., intensity and phase retardation) on a 3D OCT phantom, molded plastics, ex vivo chicken breast tissue, and ex vivo human breast cancer tissue.

© 2021 Optical Society of America

Computational refocusing in phase-unstable polarization-sensitive optical coherence tomography

Sebastián Ruiz-Lopera, René Restrepo, Taylor M. Cannon, Martin Villiger, Brett E. Bouma, and Néstor Uribe-Patarroyo
Opt. Lett. 48(18) 4765-4768 (2023)

Computational adaptive optics in phase-unstable optical coherence tomography

Sebastián Ruiz-Lopera, René Restrepo, Carlos Cuartas-Vélez, Brett E. Bouma, and Néstor Uribe-Patarroyo
Opt. Lett. 45(21) 5982-5985 (2020)

Local wavefront mapping in tissue using computational adaptive optics OCT

Fredrick A. South, Yuan-Zhi Liu, Pin-Chieh Huang, Tabea Kohlfarber, and Stephen A. Boppart
Opt. Lett. 44(5) 1186-1189 (2019)

Computational refocusing of Jones matrix polarization-sensitive optical coherence tomography and investigation of defocus-induced polarization artifacts

Lida Zhu, Shuichi Makita, Daisuke Oida, Arata Miyazawa, Kensuke Oikawa, Pradipta Mukherjee, Antonia Lichtenegger, Martin Distel, and Yoshiaki Yasuno
Biomed. Opt. Express 13(5) 2975-2994 (2022)

Birefringence and scattering characterization using polarization sensitive quantum optical coherence tomography

Vitaly Sukharenko, Simeon Bikorimana, and Roger Dorsinville
Opt. Lett. 46(12) 2799-2802 (2021)