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Nakagami statistics-based photoacoustic spectroscopy used for label-free assessment of bone tissue

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Abstract

Quick identification of abnormal molecular metabolism of bone tissues is challenging. Photoacoustic (PA) spectroscopy techniques have great potential in molecular imaging. However, most of them are amplitude-dependent and easily affected by the light deposition, especially for bone tissues with high optical scattering. In this Letter, we propose a Nakagami statistics-based PA spectroscopy (NSPS) method for characterizing molecules in bone tissues. We indicate that the NSPS curve can intelligently identify changes in the content of molecules in bone tissues, with a high disturbance-resisting ability. The NSPS has remarkable potential for use in the early and rapid detection of bone diseases.

© 2023 Optica Publishing Group

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Corrections

26 January 2023: Typographical corrections were made to the author listing and the main text.


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Supplementary Material (1)

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Supplement 1       Supplement1, including Sction1-4

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Data underlying the results presented in this paper are not publicly available at this time but may be obtained from the authors upon reasonable request.

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