Abstract

A fundamental limitation in all visible-light molecular-imaging systems has been the strong scattering of light in biological tissues, which has limited molecular imaging to superficially thin tissue slices, exposed surfaces, or diffuse, blurry images of whole animals. This year, our group outlined a process for using thin sheets of ionizing radiation to induce optical Cherenkov light excitation in thick scattering media, converting the thick-tissue imaging problem into a linear inversion that provides high-resolution localization of molecular signals from inside the animal.

© 2016 Optical Society of America