Abstract

Traditional light-field microscopy (LFM) relies on the intermediate reconstruction of visual renderings, followed by digital analysis, which applications in deeper layers of the brain as optical scattering destroys image quality. We have developed an LFM technique that eliminates the need to reconstruct a volume image, instead detecting and localizing neurons by leveraging the sparsity of brain activity in space and time for better performance in highly scattering environments.

© 2016 Optical Society of America