Here the authors present a low-cost, simple and high-throughput droplet microfluidic-based method for the production of novel barcode composite microbeads at kilohertz rates. Multiple polystyrene fluorescently-doped particles, working as whispering gallery mode cavities, were embedded inside polyacrylamide microbeads. A unique correlation exists between the diameter of the embedded particles and the excited resonance peaks, providing an identifiable signature. The combination of particles with stochastically distributed diameters served to generate millions of spectral signatures used as optically readable barcodes. The flexibility of the presented method allows a fine and tailored adjustment of the composite microbead final properties to match different requirements. This can empower their use in existing and forthcoming microfluidic platforms for disparate biochemical, biophysical and biomedical applications.
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