Daniel Razansky and his team have made a big step forward in optoacoustic imaging toward non-invasive functional human brain imaging. Optoacoustic imaging (also known as photoacoustic imaging) is an emerging medical imaging technology that promises medical applications in fundamental research and clinical translations. Translating optoacoustic imaging to non-invasive transcranial adult human brain imaging will greatly benefit our understanding of the brain thanks to its linear detection of oxy- and deoxy-hemoglobin concentrations. However, acoustic attenuation and other distortions introduced by the skull present a big challenge for transcranial imaging of the human brain. Recently, Daniel Razansky et al. developed a non-invasive transcranial multi-spectral optoacoustic angiography of pial veins through the temporal bone of an adult human. Later, they coregistered the optoacoustic images with the well-established magnetic resonance imaging (MRI) technique and validated the transcranial observation of pial vasculature. This work paves the way toward non-invasive functional human brain optoacoustic imaging in health and disease.

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