Laser Ablation of Biological Tissue with a 2.94 μm Picosecond Optical Parametric Amplifier for Ambient Mass Spectrometry Imaging

Yu Wang; Ronan A. Battle; Daniel Simon; Daniel Simon; Yuchen Xiang; Samuel F. Azevedo Magalhães; Samuel F. Azevedo Magalhães; Kenneth N. Robinson; Kenneth N. Robinson; Timothy H. Runcorn; Zoltan Takats; Zoltan Takats; Robert T. Murray

doi:10.1364/MICS.2024.MTh3C.2

High-Brightness Sources and Light-Driven Interactions Congress
Technical Digest Series (Optica Publishing Group, 2024),
paper MTh3C.2
•https://doi.org/10.1364/MICS.2024.MTh3C.2

Laser Ablation of Biological Tissue with a 2.94 μm Picosecond Optical Parametric Amplifier for Ambient Mass Spectrometry Imaging

Yu Wang, Ronan A. Battle, Daniel Simon, Yuchen Xiang, Samuel F. Azevedo Magalhães, Kenneth N. Robinson, Timothy H. Runcorn, Zoltan Takats, and Robert T. Murray

Mid-Infrared Coherent Sources 2024

Vienna Austria
12–14 March 2024
ISBN: 978-1-957171-35-7

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Applications of Mid-IR and THz Sources II (MTh3C)

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Y. Wang, R. A. Battle, D. Simon, Y. Xiang, S. F. Azevedo Magalhães, K. N. Robinson, T. H. Runcorn, Z. Takats, and R. T. Murray, "Laser Ablation of Biological Tissue with a 2.94 μm Picosecond Optical Parametric Amplifier for Ambient Mass Spectrometry Imaging," in High-Brightness Sources and Light-Driven Interactions Congress, Technical Digest Series (Optica Publishing Group, 2024), paper MTh3C.2.

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Abstract

We report a 2.94 μm OPA with ~100 ps pulse duration, 400 nJ pulse energy and a 500 kHz repetition rate, which enables high resolution (≤10 μm) laser desorption-based mass spectrometry imaging of biological tissue.

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