Evaluation of Cerebral Energy Demand during Graded Hypercapnia and Validation of Optical Blood Flow Measurements against ASL fMRI

Stefan A. Carp; Maria Angela Franceschini; David A. Boas; Young R. Kim

doi:10.1364/BIOMED.2010.JMA71

Biomedical Optics and 3-D Imaging
OSA Technical Digest (CD) (Optica Publishing Group, 2010),
paper JMA71
•https://doi.org/10.1364/BIOMED.2010.JMA71

Evaluation of Cerebral Energy Demand during Graded Hypercapnia and Validation of Optical Blood Flow Measurements against ASL fMRI

Stefan A. Carp, Maria Angela Franceschini, David A. Boas, and Young R. Kim

Biomedical Optics 2010

Miami, Florida United States
11–14 April 2010
ISBN: 978-1-55752-887-2

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BIOMED/DH Joint Poster Session (JMA)

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S. A. Carp, M. A. Franceschini, D. A. Boas, and Y. R. Kim, "Evaluation of Cerebral Energy Demand during Graded Hypercapnia and Validation of Optical Blood Flow Measurements against ASL fMRI," in Biomedical Optics and 3-D Imaging, OSA Technical Digest (CD) (Optica Publishing Group, 2010), paper JMA71.

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Abstract

We validate optical cerebral blood flow measurements against functional MRI in a rat model during graded hypercapnia. We test the iso-metabolic assumption and demonstrate an apaprent increase in brain metabolism at higher inhaled CO₂ levels.

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