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Conferences > BRAIN > 2023 > BM4B > BM4B.6

Structure-guided Redesign of OxyR-based Optogenetic Reporters for Sensitive Monitoring of Intracellular H2O2 Real-time

Justin Daho Lee, Yihan Wang, Amanda Nguyen, and Andre Berndt

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Abstract

OxyR is a protein exhibiting exceptional sensitivity and specificity towards H2O2. However, OxyR-based optogenetic sensors do not closely recapitulate the native sensitivity and kinetics. Here, we discuss a novel design principle for enhanced sensor performance.

© 2023 The Author(s)

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