Birefringence Microscope Design and Sample Preparation Exigencies for High-resolution Imaging of Myelin Degradation

Alexander J. Gray; Nathan Blanke; Rhiannon Robinson; Douglas L. Rosene; Irving J. Bigio; Irving J. Bigio

doi:10.1364/BRAIN.2023.BW1B.5

Biophotonics Congress: Optics in the Life Sciences 2023 (OMA, NTM, BODA, OMP, BRAIN)
Technical Digest Series (Optica Publishing Group, 2023),
paper BW1B.5
•https://doi.org/10.1364/BRAIN.2023.BW1B.5

Birefringence Microscope Design and Sample Preparation Exigencies for High-resolution Imaging of Myelin Degradation

Alexander J. Gray, Nathan Blanke, Rhiannon Robinson, Douglas L. Rosene, and Irving J. Bigio

Optics and the Brain 2023

Vancouver, British Columbia Canada
24–27 April 2023
ISBN: 978-1-957171-21-0

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Alignment of Functional Imaging to Circuit Structure and Behavior (BW1B)

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A. J. Gray, N. Blanke, R. Robinson, D. L. Rosene, and I. J. Bigio, "Birefringence Microscope Design and Sample Preparation Exigencies for High-resolution Imaging of Myelin Degradation," in Biophotonics Congress: Optics in the Life Sciences 2023 (OMA, NTM, BODA, OMP, BRAIN), Technical Digest Series (Optica Publishing Group, 2023), paper BW1B.5.

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Abstract

Structural imaging of myelin is of utmost importance for characterization of pathological changes to the brain in neurological disorders. Birefringence microscopy is used for rapid visualization of structural changes to myelin at sub-micron (<300nm) resolution.

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