Abstract
Using a newly developed 64-channel time resolved optical imaging system, we have attempted to obtain quantitative functional images of brain activity. For the human head, the reflectance tomographic imaging of the changes in oxy-hemoglobin, deoxy-hemoglobin and total hemoglobin associated with neural activation were obtained where the changes were given as absolute concentration changes. The obtained optical functional images were superimposed on 3-D images of the subject’s brain reconstructed from MRI. The activation area was found to be very reasonable. The optical imaging system employed here can be applied to subjects of all ages and used at the bedside, and thus presents new possibilities for neuropsychological studies.
© 2000 Optical Society of America
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