Multiplexed Fluorescence Lifetime in vivo FRET Imaging using a Dark Quencher

A. Rudkouskaya; S. Chen; N. Sinsuebphon; J. E. Mazurkiewicz; M. Ochoa; X. Intes; M. Barroso

doi:10.1364/OMP.2019.OW5D.4

Biophotonics Congress: Optics in the Life Sciences Congress 2019 (BODA,BRAIN,NTM,OMA,OMP)
OSA Technical Digest (Optica Publishing Group, 2019),
paper OW5D.4
•https://doi.org/10.1364/OMP.2019.OW5D.4

Multiplexed Fluorescence Lifetime in vivo FRET Imaging using a Dark Quencher

A. Rudkouskaya, S. Chen, N. Sinsuebphon, J. E. Mazurkiewicz, M. Ochoa, X. Intes, and M. Barroso

Optical Molecular Probes, Imaging and Drug Delivery 2019

Tucson, Arizona United States
14–17 April 2019
ISBN: 978-1-943580-54-5

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Fluorescence Lifetime Imaging and Photoacoustic Imaging (OW5D)

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A. Rudkouskaya, S. Chen, N. Sinsuebphon, J. E. Mazurkiewicz, M. Ochoa, X. Intes, and M. Barroso, "Multiplexed Fluorescence Lifetime in vivo FRET Imaging using a Dark Quencher," in Biophotonics Congress: Optics in the Life Sciences Congress 2019 (BODA,BRAIN,NTM,OMA,OMP), OSA Technical Digest (Optica Publishing Group, 2019), paper OW5D.4.

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Abstract

We report the characterization of multiplexed lifetime FRET imaging in biological samples by leveraging the dark quencher IRdye QC-1. QC-1 allows to quantify non-invasively ligand-target engagement of multiple receptors in live animals bearing tumor xenografts.

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