Abstract
The accumulation of fluorescent protoporphyrin IX following oral delivery of 5-aminolevulinic acid proved highly specific for malignant glioma. Fluorescence imaging by surgical microscopes delineates tumor from normal brain during surgical resection. This approach enables a significant increase of cases with “safe gross total resection”, associated with longer progression free survival. Limitations and possible improvements are discussed.
© 2016 Optical Society of America
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