Jiajia Ge,1,2
Sarah J. Erickson,1,3
and Anuradha Godavarty1,*
1Department of Biomedical Engineering, Optical Imaging Laboratory, EC 2675, Florida International University, 10555 West Flagler Street, Miami, Florida 33174, USA
Jiajia Ge, Sarah J. Erickson, and Anuradha Godavarty, "Multi-projection fluorescence optical tomography using a handheld-probe-based optical imager: phantom studies," Appl. Opt. 49, 4343-4354 (2010)
A handheld-probe-based optical imager has recently been developed toward
three-dimensional tomography. In this study, the improvement of target depth recovery
was demonstrated using a multi-projection technique on large slab phantoms using fluorescing target(s) (with contrast ratio) of 1.5 to deep. Tomographic results using single- and multi- (here dual)
projection measurements (with and without a priori information of
target location) were compared. In all experimental cases, the use of
multi-projection measurements along with a priori information
recovered target depth and location closer to their true values, demonstrating its
applicability for clinical translation.
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Absorption coefficient of the fluorophores at excitation wavelengths.
Absorption coefficient of the chromophores at excitation wavelengths.
Absorption coefficient of the fluorophores at emission wavelengths.
Absorption coefficient of the chromophores at emission wavelengths.
Scattering coefficient of the chromophores at excitation wavelengths.
Scattering coefficient of the chromophores at emission wavelengths.
Quantum efficiency of ICG.
Lifetime of ICG.
Table 2
Target Location Details for All Experimental Cases
Case #
Target Location (cm)
Target Depth (cm)
Side A
Side B
Side C
Side D
1
[1.5, 2.5, 2]
2
1.5
8
8.5
2
[2, 2.5, 2]
2
2
8
8
3
[2.5, 2.5, 2]
2
2.5
8
7.5
4
[2, 2.5, 2.5]
2.5
2
7.5
8
5
[2.5, 2.5, 2.5]
2.5
2.5
7.5
7.5
Table 3
Details of Multi-Projection-Based Fluorescence-Enhanced Optical Tomography
Studies
Absorption coefficient of the fluorophores at excitation wavelengths.
Absorption coefficient of the chromophores at excitation wavelengths.
Absorption coefficient of the fluorophores at emission wavelengths.
Absorption coefficient of the chromophores at emission wavelengths.
Scattering coefficient of the chromophores at excitation wavelengths.
Scattering coefficient of the chromophores at emission wavelengths.
Quantum efficiency of ICG.
Lifetime of ICG.
Table 2
Target Location Details for All Experimental Cases
Case #
Target Location (cm)
Target Depth (cm)
Side A
Side B
Side C
Side D
1
[1.5, 2.5, 2]
2
1.5
8
8.5
2
[2, 2.5, 2]
2
2
8
8
3
[2.5, 2.5, 2]
2
2.5
8
7.5
4
[2, 2.5, 2.5]
2.5
2
7.5
8
5
[2.5, 2.5, 2.5]
2.5
2.5
7.5
7.5
Table 3
Details of Multi-Projection-Based Fluorescence-Enhanced Optical Tomography
Studies