Abstract
A factor that limits the use of multiphoton microscopy (MPM) in clinical and preclinical studies is the lack of a compact and flexible probe. We report on a miniaturized MPM probe employing a microelectromechanical system (MEMS) scanning mirror and a double-clad photonic crystal fiber (DCPCF). The use of a MEMS mirror and a DCPCF provides many advantages, such as size reduction, rapid and precise scanning, efficient delivery of short pulses, and high collection efficiency of fluorescent signals. The completed probe was 1 cm in outer diameter and in length. The developed probe was integrated into an MPM system and used to image fluorescent beads, paper, and biological specimens.
© 2008 Optical Society of America
Full Article | PDF ArticleMore Like This
Sung-Liang Chen, Zhixing Xie, Tao Ling, L. Jay Guo, Xunbin Wei, and Xueding Wang
Opt. Lett. 37(20) 4263-4265 (2012)
Wibool Piyawattanametha, Eric D. Cocker, Laurie D. Burns, Robert P. J. Barretto, Juergen C. Jung, Hyejun Ra, Olav Solgaard, and Mark J. Schnitzer
Opt. Lett. 34(15) 2309-2311 (2009)
Bin He, Lei Xi, Sean R. Samuelson, Huikai Xie, Lily Yang, and Huabei Jiang
Appl. Opt. 51(20) 4678-4683 (2012)