Dual-LC PSHG microscopy for imaging collagen type I and type II gels with pixel-resolution analysis

Chung-Hwan Chen, Anupama Venugopalan Nair, Shu-Chun Chuang, Yi-Shan Lin, Mei-Hsin Cheng, Chun-Yu Lin, Chia-Ying Chang, Shean-Jen Chen, and Chi-Hsiang Lien

Biomed. Opt. Express 12(5), 3050-3065 (2021)  View: HTML | PDF

Three-dimensional imaging through turbid media using deep learning: NIR transillumination imaging of animal bodies

To Ni Phan Van, Trung Nghia Tran, Hiroshi Inujima, and Koichi Shimizu

Biomed. Opt. Express 12(5), 2873-2887 (2021)  View: HTML | PDF

High frame rate video mosaicking microendoscope to image large regions of intact tissue with subcellular resolution

Brady Hunt, Jackson Coole, David Brenes, Alex Kortum, Ruchika Mitbander, Imran Vohra, Jennifer Carns, Richard Schwarz, and Rebecca Richards-Kortum

Biomed. Opt. Express 12(5), 2800-2812 (2021)  View: HTML | PDF  [Suppl. Mat. (5)]

Scattering oblique plane microscopy for in-vivo blood cell imaging

Gregory N. McKay, Ryan C. Niemeier, Carlos Castro-González, and Nicholas J. Durr

Biomed. Opt. Express 12(5), 2575-2585 (2021)  View: HTML | PDF  [Suppl. Mat. (1)]

Design of experiments for the optimization of SOFI super-resolution microscopy imaging

Dario Cevoli, Raffaele Vitale, Wim Vandenberg, Siewert Hugelier, Robin Van den Eynde, Peter Dedecker, and Cyril Ruckebusch

Biomed. Opt. Express 12(5), 2617-2630 (2021)  View: HTML | PDF  [Suppl. Mat. (1)]

Joint regression-classification deep learning framework for analyzing fluorescence lifetime images using NADH and FAD

Lopamudra Mukherjee, Md Abdul Kader Sagar, Jonathan N. Ouellette, Jyoti J. Watters, and Kevin W. Eliceiri

Biomed. Opt. Express 12(5), 2703-2719 (2021)  View: HTML | PDF

ML-SIM: universal reconstruction of structured illumination microscopy images using transfer learning

Charles N. Christensen, Edward N. Ward, Meng Lu, Pietro Lio, and Clemens F. Kaminski

Biomed. Opt. Express 12(5), 2720-2733 (2021)  View: HTML | PDF  [Suppl. Mat. (2)]

Deep learning provides high accuracy in automated chondrocyte viability assessment in articular cartilage using nonlinear optical microscopy

Xun Chen, Yang Li, Nicole Wyman, Zheng Zhang, Hongming Fan, Michael Le, Steven Gannon, Chelsea Rose, Zhao Zhang, Jeremy Mercuri, Hai Yao, Bruce Gao, Shane Woolf, Thierry Pécot, and Tong Ye

Biomed. Opt. Express 12(5), 2759-2772 (2021)  View: HTML | PDF  [Suppl. Mat. (2)]

Structure and refractive index of fibrin protofibril aggregates according to laser phase microscopy accompanied by DLS and AFM

M. N. Kirichenko, A. V. Shkirin, L. L. Chaikov, A. V. Simakin, N. V. Tcherniega, and S. V. Gudkov

Biomed. Opt. Express 12(5), 2938-2951 (2021)  View: HTML | PDF

Laser-induced injury of the skin: validation of a computer model to predict thresholds

Mathieu Jean and Karl Schulmeister

Biomed. Opt. Express 12(5), 2586-2603 (2021)  View: HTML | PDF  [Suppl. Mat. (1)]

Tissue self-attention network for the segmentation of optical coherence tomography images on the esophagus

Cong Wang and Meng Gan

Biomed. Opt. Express 12(5), 2631-2646 (2021)  View: HTML | PDF

Extraordinary sensitivity enhancement of Ag-Au alloy nanohole arrays for label-free detection of Escherichia Coli

Charles Soon Hong Hwang, Myeong-su Ahn, and Ki-Hun Jeong

Biomed. Opt. Express 12(5), 2734-2743 (2021)  View: HTML | PDF

Hydrophobin HGFI assisted immunobiologic sensor based on a cascaded taper integrated ultra-long-period fiber grating

Binbin Song, Chang Jin, Bo Wang, Jixuan Wu, Bo Liu, Wei Lin, Wei Huang, Shaoxiang Duan, and Mingqiang Qiao

Biomed. Opt. Express 12(5), 2790-2799 (2021)  View: HTML | PDF

Cavity length control for Fourier domain mode locked (FDML) lasers with µm precision

Simon Lotz, Christin Grill, Madita Göb, Wolfgang Draxinger, Jan Philip Kolb, and Robert Huber

Biomed. Opt. Express 12(5), 2604-2616 (2021)  View: HTML | PDF

Quantitative characterization of human breast tissue based on deep learning segmentation of 3D optical coherence tomography images

Yuwei Liu, Roberto Adamson, Mark Galan, Basil Hubbi, and Xuan Liu

Biomed. Opt. Express 12(5), 2647-2660 (2021)  View: HTML | PDF

Functional optoretinography: concurrent OCT monitoring of intrinsic signal amplitude and phase dynamics in human photoreceptors

Guangying Ma, Taeyoon Son, Tae-Hoon Kim, and Xincheng Yao

Biomed. Opt. Express 12(5), 2661-2669 (2021)  View: HTML | PDF

Mirau-type full-field optical coherence tomography with switchable partially spatially coherent illumination modes

Tuan-Shu Ho, Ming-Rung Tsai, Chih-Wei Lu, Hung-Sheng Chang, and Sheng-Lung Huang

Biomed. Opt. Express 12(5), 2670-2683 (2021)  View: HTML | PDF

Automatic detection of retinopathy with optical coherence tomography images via a semi-supervised deep learning method

Yuemei Luo, Qing Xu, Ruibing Jin, Min Wu, and Linbo Liu

Biomed. Opt. Express 12(5), 2684-2702 (2021)  View: HTML | PDF

Attenuation coefficient estimation in Fourier-domain OCT of multi-layered phantoms

Babak Ghafaryasl, Koenraad A. Vermeer, Jeroen Kalkman, Tom Callewaert, Johannes F. de Boer, and Lucas J. van Vliet

Biomed. Opt. Express 12(5), 2744-2758 (2021)  View: HTML | PDF

Quantification of intermittent retinal capillary perfusion in sickle cell disease

Davis B. Zhou, Maria V. Castanos, Alexander Pinhas, Peter Gillette, Justin V. Migacz, Richard B. Rosen, Jeffrey Glassberg, and Toco Y. P. Chui

Biomed. Opt. Express 12(5), 2825-2840 (2021)  View: HTML | PDF  [Suppl. Mat. (1)]

Differentiation of breast tissue types for surgical margin assessment using machine learning and polarization-sensitive optical coherence tomography

Dan Zhu, Jianfeng Wang, Marina Marjanovic, Eric J. Chaney, Kimberly A. Cradock, Anna M. Higham, Zheng G. Liu, Zhishan Gao, and Stephen A. Boppart

Biomed. Opt. Express 12(5), 3021-3036 (2021)  View: HTML | PDF

Machine learning-based LIBS spectrum analysis of human blood plasma allows ovarian cancer diagnosis

Zengqi Yue, Chen Sun, Fengye Chen, Yuqing Zhang, Weijie Xu, Sahar Shabbir, Long Zou, Weiguo Lu, Wei Wang, Zhenwei Xie, Lanyun Zhou, Yan Lu, and Jin Yu

Biomed. Opt. Express 12(5), 2559-2574 (2021)  View: HTML | PDF  [Suppl. Mat. (1)]

Membranous nephropathy classification using microscopic hyperspectral imaging and tensor patch-based discriminative linear regression

Meng Lv, Tianhong Chen, Yue Yang, Tianqi Tu, Nianrong Zhang, Wenge Li, and Wei Li

Biomed. Opt. Express 12(5), 2968-2978 (2021)  View: HTML | PDF

Label-free identification of human coronary atherosclerotic plaque based on a three-dimensional quantitative assessment of multiphoton microscopy images

Rongli Zhang, Zhongbiao Xu, Junhai Hao, Jia Yu, Zhiyi Liu, Shun Liu, Wanwen Chen, Jiahui Zhou, Hui Li, Zhanyi Lin, and Wei Zheng

Biomed. Opt. Express 12(5), 2979-2995 (2021)  View: HTML | PDF  [Suppl. Mat. (1)]

Raman spectroscopy for guidance of vulvar cancer surgery: a pilot study

Helena C. van Doorn, Elisa M. Barroso, Senada Koljenović, Patricia C. Ewing-Graham, M. Rosa N. Soares, Nick J. van de Berg, Tom C. Bakker Schut, and Gerwin J. Puppels

Biomed. Opt. Express 12(5), 3008-3020 (2021)  View: HTML | PDF

Quasi-distributed fiber optic sensor-based control system for interstitial laser ablation of tissue: theoretical and experimental investigations

Leonardo Bianchi, Sanzhar Korganbayev, Annalisa Orrico, Martina De Landro, and Paola Saccomandi

Biomed. Opt. Express 12(5), 2841-2858 (2021)  View: HTML | PDF  [Suppl. Mat. (2)]

Low noise, self-phase-modulation-enabled femtosecond fiber sources tunable in 740-1236 nm for wide two-photon fluorescence microscopy applications

Lu-Ting Chou, Yu-Cheng Liu, Dong-Lin Zhong, Wei-Zhong Lin, Hao-Hsuan Hung, Chao-Jin Chan, Zi-Ping Chen, and Shih-Hsuan Chia

Biomed. Opt. Express 12(5), 2888-2901 (2021)  View: HTML | PDF

Centimeter-scale wide-field-of-view laser-scanning photoacoustic microscopy for subcutaneous microvasculature in vivo

Tangyun Liao, Yuan Liu, Junwei Wu, Lijun Deng, Yu Deng, Lvming Zeng, and Xuanrong Ji

Biomed. Opt. Express 12(5), 2996-3007 (2021)  View: HTML | PDF

Reducing the effects of parallax in camera-based pulse-oximetry

Mark van Gastel, Wenjin Wang, and Wim Verkruysse

Biomed. Opt. Express 12(5), 2813-2824 (2021)  View: HTML | PDF

Spatiotemporal monitoring of changes in oxy/deoxy-hemoglobin concentration and blood pulsation on human skin using smartphone-enabled remote multispectral photoplethysmography

Qinghua He, Zhiyuan Sun, Yuandong Li, Wendy Wang, and Ruikang K. Wang

Biomed. Opt. Express 12(5), 2919-2937 (2021)  View: HTML | PDF

Disrupted signal variability of spontaneous neural activity in children with attention-deficit/hyperactivity disorder

Zhenyan Hu, Lu Liu, Mengjing Wang, Gaoding Jia, Haimei Li, Feifei Si, Min Dong, Qiujin Qian, and HaiJing Niu

Biomed. Opt. Express 12(5), 3037-3049 (2021)  View: HTML | PDF  [Suppl. Mat. (1)]

Effect of cataract-induced refractive change on intraocular lens power formula predictions

David L. Cooke, Timothy L. Cooke, and David A. Atchison

Biomed. Opt. Express 12(5), 2550-2556 (2021)  View: HTML | PDF

Multiple Lesions Insertion: boosting diabetic retinopathy screening through Poisson editing

Zekuan Yu, Rongyao Yan, Yuanyuan Yu, Xiao Ma, Xiao Liu, Jie Liu, Qiushi Ren, and Yanye Lu

Biomed. Opt. Express 12(5), 2773-2789 (2021)  View: HTML | PDF

Vision with spatial light modulator simulating multifocal contact lenses in an adaptive optics system

Shrilekha Vedhakrishnan, Maria Vinas, Sara Aissati, and Susana Marcos

Biomed. Opt. Express 12(5), 2859-2872 (2021)  View: HTML | PDF

Visual performance after the deterioration of retinal image quality: induced forward scattering using Bangerter foils and fog filters

José J. Castro-Torres, Francesco Martino, Miriam Casares-López, Sonia Ortiz-Peregrina, and Carolina Ortiz

Biomed. Opt. Express 12(5), 2902-2918 (2021)  View: HTML | PDF

Assessment of radiotherapy effect for nasopharyngeal cancer using plasma surface-enhanced Raman spectroscopy technology: errata

Qiong Wu, Sufang Qiu, Yun Yu, Weiwei Chen, Huijing Lin, Duo Lin, Shangyuan Feng, and Rong Chen

Biomed. Opt. Express 12(5), 2557-2558 (2021)  View: HTML | PDF