Abstract
It is well-known that the wave of a freely propagating Gaussian beam experiences an additional π phase shift compared to a plane wave. This phase shift, known as the Gouy phase, has significant consequences in, e.g., nonlinear optics, since the nonlinear processes require high peak intensity and phase matching of the focused beams. Hence, determining and controlling the Gouy phase is crucial in many fields of modern optics and photonics. Here, we develop an analytical model for the Gouy phase of long-range Bessel-Gaussian beams obtained by annihilating highly charged optical vortices. The model accounts for the influence of the relevant experimental parameters (topological charge, radius-to-width ratio of the initial ring-shaped beam, and focal length of the Fourier-transforming lens). We find an evolution of the Gouy phase varying nearly linearly with propagation distance and confirm this result experimentally.
© 2023 Optica Publishing Group under the terms of the Optica Open Access Publishing Agreement
1. Introduction
One of the phenomena that is assumed to be well understood, but still provokes serious scientific interest, is that any focused light beam experiences an axial phase shift with respect to a reference plane wave when passing through its focus. This phase anomaly was first studied by Gouy and is named after him. The chronology of early studies can be read in the work of Linfoot and Wolf [1]. Later, most of the studies were related to the development of microwave optics (see e.g. [2,3]), lasers (see e.g. [4]), nonlinear optics [5], terahertz radiation [6,7], and singular optics of phase [8,9] and polarization vortices [10,11], including hybrid singularities [12]. The Gouy phase has important consequences in, e.g., nonlinear optics. In general, the $n$-th order nonlinear polarization will experience a phase shift that is $n$ times larger than that experienced by the incident pump wave [13,14]. As a consequence, the efficiency of third-harmonic generation in the tight-focusing limit, for example, vanishes for the case of perfect phase matching. It can be optimized by introducing a linear wave vector mismatch for compensating the Gouy phase shift [13]. Conversion between Laguerre-Gaussian modes via four-wave mixing in the thick-medium regime (in essence the transfer between azimuthal and radial mode indices) is also observed and explained by the influence of the Gouy phase [15]. It is natural to expect that the Gouy phase also has profound consequences in highly nonlinear processes like above-threshold ionization [16] and high-harmonic generation [17].
Let us denote by $L_D$ and $z$ the Rayleigh diffraction length and the longitudinal coordinate, respectively. Then, the Gouy phase for a fundamental Gaussian beam is given by $\Phi _G$=atan$(z/L_D)$. For a higher-order Hermite-Gaussian mode with mode indices ($n,m$) this phase is multiplied by a factor of (1+$m$+$n$) [18]. For a higher-order Laguerre-Gaussian modes with mode indices ($\ell,p$) the factor is (1+|$\ell$|+2$p$) [19,20]. Here, the modulus accounts for the fact that the azimuthal mode index $\ell$ (i.e. the on-axis topological charge (TC) of the point-phase dislocation known as optical vortex (OV)) can either be positive or negative. The factor 2 is related to the fact that $p$ is the radial mode index of the LG beam. Generally speaking, passing through the focal plane, higher-order Hermite-Gaussian and Laguerre-Gaussian modes accumulate a higher Gouy phase with respect to a reference Gaussian beam. This has been proven experimentally for truncated Gaussian beams as well [21].
The question we would like to address in this communication is how the Gouy phase behaves in Bessel-Gaussian beams. Bessel beams are one of the four types of exact solutions of the Helmholtz equation [22]. For instance, in the pure mathematical sense, the zeroth order Bessel beam has a sharp central non-diffracting peak surrounded by an infinite number of satellite rings that are offset by $\pi$ in phase with respect to their neighbor. An infinite number of surrounding rings implies infinite energy, which obviously is not possible for (Gaussian) laser beams with finite transverse dimensions. Viable approximations to Bessel beams have a Gaussian envelope and are usually denoted as Bessel-Gaussian beams (BGBs). Their central peaks (for higher order BGBs: rings) are remarkably resistant against diffraction. Therefore, BGBs are sometimes denoted as "non-diffracting", "quasi-non-diffracting" or "diffraction-free" in the literature [23–25].
Well-known methods for generating BGBs are annular slits in the back focal plane of a lens [23,24,26] or even a cylindrical lens morphed to a closed ring [27]. Other methods use axicons [26], or deformable mirrors [28], or spatial light modulators reproducing the phase structures of reflective axicons [29], or computer-generated holograms of axicons [30]. In previous studies, we have demonstrated the possibility to generate long-range BGBs by creating and annihilating highly charged optical vortices [31,32]. The method was demonstrated to work even for sub-7-femtosecond pulses [33].
Due to the extended interaction length of the Bessel-Gaussian beams, they find application in many fields of physics, e.g. in plasma physics [34,35] and in strong-field physics [17,36]. An interesting application of BGBs benefiting from their extended range of strong focusing might be high-harmonic generation (HHG) [37,38]. Then, immediate question concerns the Gouy phase in long-range BGBs because of its impact on phase matching of high harmonics.
The Gouy phase is quantified on the axis of a real beam relative to a reference infinite plane wave, which, since not spatially confined, does not diffract. The central peaks of Bessel-Gaussian beams (BGBs) have remarkably low divergences on the order of microradians [27,31]. Therefore, one might guess that BGBs have negligible Gouy phase. However, the two experimental works we are aware of [8,39] found that for strong focusing the Gouy phase of BGBs changes linearly for propagation distances of fractions of millimeters (up to 5$\pi$ within 1 mm [8] and up to 6$\pi$ within 6 µm [39]).
In this work we develop an analytical model for the Gouy phase of long-range BGBs that accounts for the relevant experimental parameters. The analytical results are found to be in good quantitative agreement with the experimental data. In particular, under relatively weak focusing of the initial hollow ring-shaped beam (lens’ focal lengths 40-75 cm), the Gouy phase of the BGB is found to change nearly linearly at a rate of some 0.15 $\pi$/cm over a distance of 45 cm. Under moderate focusing (with a lens focal length $\sim$15 cm), the linear vs. propagation distance Gouy phase reaches a slope of 1.0 $\pi$/mm over distances exceeding 4 mm. The reported data could appear important for the phase matching in the process of high-harmonics generation [40] when using BGBs as opposed to conventional Gaussian beams (see e.g. [37,38]).
2. Theoretical model
2.1 Elementary theory
We start with the insight that the wave vectors $\vec {k}$ of confined beams necessarily have a transverse component $k_t$. Since $k^2 = k_t^2 + k_z^2$, where $k_z$ is the longitudinal component of the wavenumber $k$, this means that a finite transversal wave number $k_t$ goes at the expense of $k_z$: The narrower the BGB, the larger $k_t$ and the smaller $k_z$. This results in an effectively increasing wavelength (or a phase advancing faster than the speed of light), which can be seen as the physical origin of the Gouy phase.
The accumulated phase difference $\Delta \phi$ between a Bessel beam and a plane wave is
where $z$ is distance along the optical axis. Then the distance $\mathcal {D}$ for a phase difference of $2 \pi$ is In order to estimate transversal wave number $k_t$, we note that the first zero of $J_0(x)$ is at $x=2.4048\cdots$. Therefore, when $\rho$ is the radius of the central peak of the Bessel beam, $k_t$ can be estimated asUsing the approximation $k_z = \sqrt {k^2 - k_t^2} \approx k - \frac {k_t^2}{2 \, k}$, i.e. limiting the Taylor expansion at $k=0$ to second order ($k_t \ll k$), we get
which, along with Eq. (2) and the fact that $k = \frac {2 \pi }{ \lambda }$ implies that2.2 Derivation of the Fourier transform leading to Bessel-Gaussian beams
Let $\mathcal {F}\{U\}$ denote the Fourier transform of a function $U(x,y)$ and $\mathcal {H}_\ell \{U(r)\}$ stand for the Hankel transform of order $\ell$ of a radially symmetric function. The Fourier conjugate variables corresponding to Cartesian coordinates $(x,y)$ and polar coordinates ($r,\theta$) will be denoted by $(u,v)$ and $(\rho,\varphi )$, respectively. We will also denote the Fourier transform of $U(r, \theta )$ as $U(\rho, \varphi )$ where convenient and where the context is unambiguous.
Let us consider $U(r, \theta )$ as a function separable in polar coordinates, i.e. $U(r, \theta ) = R(r) F(\theta )$. Then one can do the following expansion [41]
Another important identity that we need is [42]
Let
where $\omega _0$ and $r_0$ are positive real parameters. The physical meaning of Eq. (11) is the description of the electric field amplitude $E$ of a bright ring-shaped beam with radius $r_0$ and ring width $\omega _0$ (panel (a) of Fig. 1). It is a very good approximation for an optical vortex with a topological charge $\ell$ ($\ell$ is an integer number). The phase distribution for $\ell =+1$ and $\ell =-9$ is displayed in Fig. 1, panels (b) and (c).By expanding the square we get
2.3 Gouy phase of a BGB obtained by direct comparison with a plane wave
Let us consider the general Bessel-Gaussian solution of the scalar Helmholtz equation, given by Gori et al. [43]
2.4 Effect of the focal length of the lens
A thin lens acts as a Fourier-transforming element (see Section 5.2.2 in [41]). Let $f$ be the focal length of the lens and $k$ the wave number. For an initial electric field amplitude $U(x,y)$, after the lens we have
Equation (5) clearly shows that the distance to be passed for a $2\pi$ phase shift is shorter for BGBs with narrower central peaks, i.e. for BGBs created with lenses of shorter focal lengths and with ring-shaped beams of larger radii. From Eq. (3) we can see that $k_t$ is the coefficient $\beta$ in Eqs. (17) and (30). Now, let us consider $\psi _1$ from Eq. (25). (We took the sign to be positive, since it makes no difference.) The distance, needed for a $2\pi$ phase shift is
3. Experimental comparison with the theoretical results
3.1 Experimental schemes
For the experiments we used two different arrangements. The setup shown in Fig. 3(a) is used to study the Gouy phase of BGBs under relatively weak focusing (lens’ focal lengths 40-75 cm). A continuous-wave beam from a frequency-doubled Neodymium-doped Yttrium Orthovanadate (Nd:YVO$_4$) laser (wavelength of 532 nm) was expanded and split to form an object and a reference arm. Passing through the object arm, it is reflected twice from the liquid-crystal spatial light modulators SLM1 and SLM2 (1920 pix $\times$ 1080 pix with a pixel pitch of 8 µm and SLM1-to-SLM2 distance of 49 cm). On SLM1 the phase of the desired highly-charged OV is encoded. During propagation towards SLM2, this OV decays into singly-charged OVs which repel each other and reorder in a ring thus generating a ring-shaped beam (see e.g. panel (a) in Fig. 1). This beam still carries point phase singularities, which need to be removed. Since the SLMs are reflective and reflection inverts the sign of TCs, we encode the phase of the same highly-charged OV on SLM2 for subsequent zeroth-order BGB generation. After all TCs of the OVs are erased, the required hollow ring-shaped beam is Fourier transformed in space. This is done by using thin plano-convex lenses with focal lengths $f =$ 75 cm, 50 cm, and 40 cm and diameters of 2.5 cm. Recorded frames of the ring-shaped beam in front of the Fourier-transforming lens and of the generated BGB at a propagation distance of 40 cm behind the focus are shown in Fig. 3, frames (a2) and (a3) respectively. The object and the reference beams are recombined by a second beam splitter to interfere on a CCD camera’s chip. The CCD camera is mounted on a rail to allow recording of interference patterns at varying propagation distances.
The setup shown in Fig. 3(b), enabling interferometry for moderate and tight focusing, is a modification to the one shown in Fig. 3(a) in the sense that lens L2 is located approximately at the position of the dashed rectangle in Fig. 3(a). The reference beam is blocked and the second BS removed, while the focusing lens L1 is left unchanged and the CCD camera is relocated close to lens L2. After this modification, lens L1 is still playing the role of the Fourier-transforming element for the ring-shaped beam, thus generating the BGB. The long dash-dotted vertical line (at position 1) is intended to mark the distance at which the main BGB is already well developed. Lens L2 is placed in such a way that it focuses this BGB. It is important to note that in and after the focus of L2 (leftmost dashed vertical line, position 3) the converging BGB is inversely Fourier transformed into a ring-shaped beam. Until then it is propagating as a Bessel-Gaussian beam.
Lens L1 has a focal length of $75$ cm, while L2 has $100$ cm. In addition, lens L2 has no antireflection coating. Due to this fact, after two weak Fresnel reflections from its surfaces, a “ghost” BGB is formed at a much shorter distance (14.6 cm) than the focal length of L2. This “ghost” BGB is co-axial with respect to the main “background” BGB (see the tiny dark green lines inside lens L2 in Fig. 3(b)). The central peak of the host BGB effectively serves as a reference beam in the very short single-lens interferometer. Within this distance the weakly focused host BGB is only slightly reshaped. A clear interference pattern between the central peak of main BGB and the “ghost” can be observed in a short range of distances near L2. A detailed description of single-lens interferometers can be found in [44,45].
Since the single-lens interferometer is a frugal but not very popular device [45], we demonstrate its use with a Gaussian laser beam in Fig. 4. According to [44] the effective focal length of the lens forming the single-lens interferometer is
where $n$ is the refractive index of the material and $f$ is the focal length of the lens. For the used N-BK7 lens with $f = 100$ cm the focal plane is estimated to be located 14.6 cm behind the lens. The left two frames in Fig. 4 show interferograms recorded at distances of $\pm$7.5 mm from the focus of the "ghost" beam. Their symmetrical displacement relative to the focus can be recognized by the change in the angle of the moderately pronounced ellipticity of the interference rings. The ellipticity of the Gaussian beam (the ratio of the major to the minor axis of the ellipse) was estimated to be 1.15. Elliptic beam profiles result in different Rayleigh diffraction lengths along the major and the minor axis of the elliptical beam, thus affecting the Gouy phase measurement. The mentioned estimated ellipticity results in a 15 % difference between the Rayleigh diffraction lengths along the two axes (see dashed curves in Fig. 4(c)).An important fact is the significant change in the interference pattern along the beam axis – from a relatively low on-axis intensity level (due to a destructive interference) before the focus (e.g. at −7.5 mm) towards a global interference maximum at the focus, followed by a decrease of the on-axis interference signal (e.g. at +7.5 mm; although there is an on-axis constructive interference). This is also in agreement with the data in Figs. 4 and 5 in [44]. The graph in Fig. 4(a) shows the essential part of the experimentally recorded on-axis interference signal vs. distance (solid squares; within an interval of 8 cm). Figure 4(b) presents the Gouy phase of the Gaussian beam retrieved from the data in Fig. 4(a), plotted in units of $\pi /2$. The data points denoted with colored circles correspond to the interferograms shown in the left two panels of this figure. The graph in Fig. 4(b) is in a good quantitative agreement with the fact that, along the optical axis around the focus, a freely propagating Gaussian "ghost" beam accumulates a $\pi$ phase shift – the Gouy phase shift. The red solid curves in both graphs in Fig. 4 are fits calculated according to the procedure for processing the experimental data presented below. Fig. 4(c) once again displays the processed experimental points for the Gouy phase shown already in graph (b), now along with two additional dashed curves. They indicate the uncertainty of the processed data when the $\pm$7.5 % uncertainty of the Rayleigh lengths due to the beam ellipticity is considered. The solid magenta curve is a plot of the analytical formula for the Gouy phase shift for a Gaussian beam with a beam radius of 35 µm at the beam waist and for $\lambda =532$ nm.
3.2 Data recording and processing
In the experimental setups shown in Fig. 3, the CCD camera is placed on a rail such that it can be translated along the beam axis (the $z$-axis in Figs. 4–8) in a well-defined way. In this manner, we are able to record interference patterns containing information on the Gouy phase vs. propagation distance. At each position, the CCD camera captures an interferogram. From each interferogram we evaluate the intensity in the center of the ring interference pattern, in the following referred to as axial interference signal. One such signal, is presented in Fig. 5(a). The sequence of operations for processing the experimental data is:
- /a/ Subtraction of a reference line from the recorded axial interference signal in order to take into account the change of the beams’ intensities;
- /b/ Shift and normalization of the experimental data to fit them into the interval [−1,1];
- /c/ Approximation of the normalized interference signal with a function of the type where $z$ is the longitudinal coordinate. The second term involving parameters $B$, $C$ and $D$ accounts for the longitudinal intensity variation of the interfering beams and $A$ is a adjustable shift. Parameters $E, F, G$ and $H$ are related to the Gouy phase, while $I$ is constant phase shift;
- /d/ Apply $\arcsin \{\sin [\cdots ]\}$ in order to transfer the obtained approximation of the experimental data to the range [-$\pi$, $\pi$];
- /e/ Unfold the obtained approximation phase to a multiple of $\pi$.
- /f/ Apply $\arcsin$-function to the experimental data and repeat the procedure in the preceding point;
- /g/ If desired for better visualization, shift the experimental data and the fit curve by the same phase. Present the propagation distance in physical units (e.g. in centimeters).
3.3 Results
Following the described procedure, we present a comparison between the experimental data and the theoretical results for different values of experimental parameters. One such parameter is the radius-to-width ratio $r_0/\omega _0$ of the ring-shaped beam prior to its final focusing (here, a lens with $f=75$ cm is used). In order to vary $r_0/\omega _0$, we intentionally changed the TCs of the initially imprinted and subsequently annihilated OVs. The proportionality of $r_0/\omega _0$ to the TC $\ell$ is in agreement with the data in Fig. 2(b) in [31]. (See also Table 1 below.) The data are obtained by using the Mach-Zehnder interferometer and refer to a relatively weak beam focusing. In Fig. 6(a) we show processed experimental data (open circles) for the longitudinal evolution of the Gouy phase of Bessel-Gaussian beams created with TCs = 9, 19, 29, 39, and 49. The absolute values |TC| are indicated to the right of the curves. The solid lines are fits obtained as described above.
Two important tendencies are evident: (i) For all TCs, i.e. for every particular value of $r_0/\omega _0$, the nearly linear dependence of $\Phi _G$ vs. $z$ is well expressed. (ii) At a constant distance, the increase of the Gouy phase with increasing |TC| (i.e. the radius-to-width ratio $r_0/\omega _0$) is in a qualitative agreement with the analytical result Eq. (32). This implies that the Gouy phase of the BGBs can be controlled without any realignment of the setup. However, for experiments where constant intensity is desired, one would need to adjust the pulse energy.
The theoretical results given by Eq. (32) are plotted in Fig. 6(b) with solid curves for the nominal focal length $f=75$ cm of the used focusing lens. A Gaussian beam, however, does not focus exactly in the focal plane of a lens [46]. Because of this, it is important to know the $z=0$ position of the focal plane of the lens. That is why we performed a calibration experiment. We concluded that the effective focal length of the used lens with nominal $f=75$ cm is 80 cm. The evolution of the Gouy phase for the nominal and experimentally determined (effective) focal lengths, computed using Eq. (32), are compared in Fig. 6(b). As seen, the longer effective focal length results in a decrease in the Gouy phase at a fixed distance.
The comparison between the experimental (Fig. 6(a)) and theoretical data (Fig. 6(b)) for the nominal $f=75$ cm at e.g. 40 cm for |TC| = 49 shows that the calculated Gouy phase is nearly 20% higher than the experimentally measured. However, this 20% higher theoretical value decreases nearly three times to approximately 7% when taking into the account the effective focal length of the used lens ($f=80$ cm). In our view, this difference is due to the sensitivity of the Gouy phase to the accuracy in determining the ring width $\omega _0$ of the ring-shaped beam prior to Fourier transformation. Additional comments regarding the origin of this error can be found in Supplement 1.
In Table 1, we summarize the experimental results for the retrieved slopes of the respective Gouy phases of the BGBs for different radius-to-width ratios. In addition, the divergence half-angles of the central peaks of the BGBs are presented. As expected (see e.g. [31]), the increase of the radius-to-width ratio $r_0/\omega _0$ of the ring-shaped beam in front of the lens leads to a decrease of the beam’s divergence. For the slope of the Gouy phase vs. |TC| the tendency is the opposite. It increases from $0.01\pi /$cm at |TC| = 9 to $0.15\pi /$cm at |TC| = 49. These slopes for the Gouy phase of BGBs referring to a relatively weak focusing are still lower than the $0.38\pi /$cm for a Gaussian beam, however the last value is estimated within its Rayleigh range (within few centimeters), while the Gouy phase of BGBs increases nearly linearly over tens of centimeters.
Another accessible experimental control parameter is the focal length of the Fourier-transforming lens L1. The data presented in Fig. 7 clearly show that the stronger the focusing of the ring-shaped beam, the higher the slope of the Gouy phase vs. propagation distance. In Fig. 7(a) we show experimental results for this dependence for BGBs generated by imprinting and annihilating TCs = 29 and −29. Three lenses with nominal focal lengths $f=75$ cm, 50 cm, and 40 cm are used. The Gouy phases calculated using Eq. (32) are shown in Fig. 7(b). The solid curves refer to the denoted and already mentioned nominal focal lengths, the dashed curves to the somewhat longer experimentally determined effective focal lengths of 80 cm, 52 cm, and 41.5 cm. For one and the same propagation distance, stronger focusing causes a larger Gouy phase shift of the BGB. The calculated phase shift surpass the measured, however the differences decrease when the effective focal lengths are accounted in the calculations instead of the nominal ones. For shorter focal lengths, the calculated Gouy phase deviates more strongly (almost by a factor of 2) from the experimental results. We attribute this discrepancy to the sensitivity of the Gouy phase to the accuracy in determining the ring width $\omega _0$ of the ring-shaped beam prior to Fourier transformation. More details can be found in Supplement 1.
Additionally, analogous to the classical $f$-number, we can define an effective $f$-number as a ratio of the lens’ focal length $f$ to the ring radius $r_0$. As seen from Eq. (32), the Gouy phase depends inversely proportional to the second power of this effective $f$-number.
We would like to show experimental data for stronger focusing (but still moderate, as compared to focusing with e.g. high numerical aperture objective [39]). This is realized by using the single-lens interferometer technique described in details in [44] and shown in Fig. 3(b). Obviously, the propagation length for the "ghost" BGB is limited, since after its focus it converts into a diverging ring-shaped beam. The host BGB (more precisely – its central peak) effectively serves as a reference beam. Within the distance of interest, the weakly focused host BGB is only slightly reshaped. Ascribing the longitudinal phase changes solely to the more strongly focused "ghost" BGB, the normalized axial signal and the data retrieved from this measurement are shown in Fig. 8(a) and (b), respectively. They clearly express the fact that a slope of the Gouy phase vs. distance of 1.0$\pi$/mm is achievable under moderate focusing (estimated focal length 14.6 cm). The reconstructed change of the Gouy phase here is almost 4$\pi$ (see Fig. 8(b)), while the Gouy phase of the Gaussian beam should saturate at larger offsets from its beam waist and should remain limited to $\pm \pi$/2.
4. Conclusion
The problem of the Gouy phase of Bessel-Gaussian beams (BGBs) still raises many questions. Its correct determination is of a great importance for many fields of modern optics. Here, we elaborated an analytical model for the Gouy phase of long-range BGBs obtained by creating and annihilating optical vortices (OVs). The model is accounting for the influence of the relevant experimental parameters: the OV’s topological charge, the ring-shaped beam’s radius-to-width ratio, and the focal length of the Fourier-transforming lens. These parameters are relevant because their combination determines the transverse component of the wave-vector. The experimental data support the model and prove the nearly linear evolution of the Gouy phase of BGBs both for long and short focal lengths. In particular, for the same ring-shaped beam and propagation distance, stronger focusing causes a larger Gouy phase shift of the BGB. Under relatively weak focusing of the initial hollow ring-shaped beam, the Gouy phase of the BGB is found to change linearly at a rate of some 0.2 $\pi$/cm over a distance of 45 cm. Under moderate focusing, the linear Gouy phase vs. propagation distance reaches a slope of 1.0 $\pi$/mm over distances exceeding 4 mm. The presented results are important in e.g., nonlinear optics in optically thick nonlinear media, where the observation of nonlinear processes requires high peak intensities and phase matching of focused beams. They may appear applicable also to filaments formation and high-harmonics generation.
Funding
Ministry of Education and Science (D01-401/18.12.2020); Deutsche Forschungsgemeinschaft (PA 730/13).
Acknowledgements
We acknowledge funding of the Deutsche Forschungsgemeinschaft (project PA PA730/13). This work was also supported by the European Regional Development Fund within the Operational Programme "Science and Education for Smart Growth 2014-2020" under the Project CoE "National center of mechatronics and clean technologies" BG05M2OP001-1.001-0008-C01 and by the Bulgarian Ministry of Education and Science as a part of National Roadmap for Research Infrastructure, grant number D01-401/18.12.2020 (ELI ERIC BG). L.S. would like to gratefully acknowledge the research scholarship granted by the Alexander von Humboldt Foundation.
Disclosures
The authors declare no conflicts of interest.
Data Availability
The datasets generated and analyzed during the current study are available from the corresponding author upon a reasonable request.
Supplemental document
See Supplement 1 for supporting content.
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