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Multi-Modality Microscopy — Combining Multiphoton and Optical Coherence Microscopy Using an Ultrafast Laser Source

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Abstract

A multi-modality microscopy system is developed where multiphoton microscopy (MPM) and optical coherence tomography (OCT) are combined on a single platform using an ultrafast Ti:Sapphire laser. The system is capable of providing simultaneous functional and structural information about biological tissues in three imaging channels including second harmonic generation, two-photon excited fluorescence, and OCT. A RAFT tissue model is imaged where the composition and structure of the extracellular matrix and cells are clearly demonstrated. Images from the study of prostate cancer are also demonstrated. This multi-modality system is potentially a powerful tool for studying biological processes such as wound healing and carcinogenesis.

© 2006 Optical Society of America

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