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Conferences > CLEO_Europe > 2023 > ch_2 > ch_2_1
  • Conference on Lasers and Electro-Optics/Europe (CLEO/Europe 2023) and European Quantum Electronics Conference (EQEC 2023)
  • Technical Digest Series (Optica Publishing Group, 2023),
  • paper ch_2_1

Deep Ensemble Learning and Transfer Learning Methods for Classification of Senescent Cells in Nonlinear Optical Microscopy Images

Francesco Manetti, Salvatore Sorrentino, Arianna Bresci, Federico Vernuccio, Chiara Ceconello, Silvia Ghislanzoni, Italia Bongarzone, Renzo Vanna, Giulio Cerullo, and Dario Polli

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Abstract

Successful chemotherapy and radiotherapy anti-cancer treatments may result in either tumour suppression or senescence induction. Until recently, experts agreed that senescence was a condition of durable growth arrest, promoting it as a favourable therapeutic outcome. However, recent advancements in oncology research evidence senescence as one of the culprits of cancer relapse [1]. Senescence is a complex phenotype, and no specific marker exists, so that multiple assays are required. A solution for fast, non-invasive, and label-free detection of therapy-induced senescent cells comes from nonlinear optical (NLO) microscopy.

© 2023 IEEE

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