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Conferences > CLEO_Europe > 2023 > cl_6 > cl_6_5
  • Conference on Lasers and Electro-Optics/Europe (CLEO/Europe 2023) and European Quantum Electronics Conference (EQEC 2023)
  • Technical Digest Series (Optica Publishing Group, 2023),
  • paper cl_6_5

Plug-and-play stimulated Raman microscopy system for broadband coherent vibrational imaging

Francesco Crisafi, Benedetta Talone, Andrea Ragni, Gabriele Di Noia, Mujeeb Rahman, Jing He, Jeremiah Marcellino, Goutam Kar, Yarjan Samad, Boyang Mao, Renzo Vanna, Franziska Hoffmann, Orlando Guntinas-Lichius, Silvia Ghislanzoni, Italia Bongarzone, Sze Yun Set, Andrea C. Ferrari, Giulio Cerullo, and Matteo Negro

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Abstract

Stimulated Raman scattering (SRS) microscopy is an emerging tool for biomedical imaging, with applications ranging from cell-drug interaction [1], cell sorting [2] to tissue analysis [3] and histopathology [4]. Current commercial systems [5] require users to deal with integration between laser, microscope and the detection system, resulting in trade-offs and, most importantly, lack of user-friendliness, thus hindering widespread application by non-specialists. This approach has pushed the laser market towards the development of high power (>100mW, >1nJ/pulse) narrowband (<1nm) tunable sources (Optical Parametric Oscillators (OPOs) and Fiber-OPOs) which can be coupled to off-the-shelf photodiodes and lock-in amplifiers, at the cost of detecting one or maximum two frequencies at a time [5].

© 2023 IEEE

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