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Nanopore fluidic SERS

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Abstract

We describe a technology combining nanopore fluidic with surface enhanced Raman spectroscopy (SERS) for real-time, single molecule detection. After optimization of both optical and device design, we can control the nanopore like a valve for molecule motions and detect a single nucleotide even at 10 ms.

© 2014 Optical Society of America

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