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  • Clinical and Biomedical Spectroscopy and Imaging III
  • SPIE Proceedings (Optica Publishing Group, 2013),
  • paper 879802

Oligonucleotide Switches and Nanomaterials for Intracellular mRNA Sensing

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Abstract

We describe here the conjugation of polymethylmethacrylate nanoparticles to particular oligonucleotide switches, termed molecular beacons (MBs), as potential intracellular nanosensors. Survivin mRNA targeting MBs have been used with Atto647N and Blackberry 650 as fluorophore/quencher pair. The nanosensors have been characterized in vitro by investigating the analytical performances of the chosen molecular beacon and its functionalities after conjugation to the nanoparticles.

© 2013 SPIE

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