Functional optical imaging of human brain activity—A study with a time-resolved optical tomographic system—

Mamoru Tamura; Yoko Hoshi

doi:10.1364/IVOI.1999.DIS89

Proceedings of Inter-Institute Workshop on In Vivo Optical Imaging at the NIH
Technical Digest Series (Optica Publishing Group, 1999),
paper DIS89
•https://doi.org/10.1364/IVOI.1999.DIS89

Functional optical imaging of human brain activity—A study with a time-resolved optical tomographic system—

Mamoru Tamura and Yoko Hoshi

In Vivo optical Imaging at the NIH 1999

Bethesda, MD United States
16–17 September 1999
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Diffuse Imaging and Spectroscopy (DIS)

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M. Tamura and Y. Hoshi, "Functional optical imaging of human brain activity—A study with a time-resolved optical tomographic system—," in Proceedings of Inter-Institute Workshop on In Vivo Optical Imaging at the NIH, Technical Digest Series (Optica Publishing Group, 1999), paper DIS89.

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Abstract

Using a newly developed 64-channel time resolved optical imaging system, we have attempted to obtain quantitative functional images of brain activity. For the human head, the reflectance tomographic imaging of the changes in oxy-hemoglobin, deoxy-hemoglobin and total hemoglobin associated with neural activation were obtained where the changes were given as absolute concentration changes. The obtained optical functional images were superimposed on 3-D images of the subject’s brain reconstructed from MRI. The activation area was found to be very reasonable. The optical imaging system employed here can be applied to subjects of all ages and used at the bedside, and thus presents new possibilities for neuropsychological studies.

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