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Conferences > LS > 2021 > JW7A > JW7A.110

Label-free interferometric scattering imaging of molecular fluctuation predicts fluorescence nuclear microscope images

Yi-Teng Hsiao, Chia-Ni Tsai, Tsai-Ying Wu, Huan-Hsin Tseng, Yu Tsao, and Chia-Lung Hsieh

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Abstract

We demonstrate a computational method to map the nuclear organization of live cells based on a deep-learning approach where the time-varying scattering signal is used to estimate the density of chromatin in the fluorescence image.

© 2021 The Author(s)

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