Abstract
Mid-infrared (MIR) (3–12 um) spectral imaging is a power analytical tool, but difficult in the back-reflectance mode for in-vivo diagnostics. Feasibility of MIR back-reflectance imaging is demonstrated using MIR semiconductor lasers. Transmittance through 500-µm thick films of water and blood showed a capability to resolve more than 6-OD signal dynamic range. Reflectance scanning imaging through a 150-µm thick film of blood showed negligible scattering effect, indicating the feasibility of optical coherent imaging. The result of coherent imaging of a plant leaf shows a MIR sub-surface image that would not be visible in white light. With two wavelengths, a similar result for a chicken skin subcutaneous tissue at different focal depths was obtained, showing blood vessels beneath a lipid layer. These results suggest that advanced multi-laser wavelength systems in the fingerprint spectral region can be a useful tool for in-vivo spectral imaging in biomedical research and diagnostic applications.
©2004 Optical Society of America
Full Article | PDF ArticleMore Like This
Jakob Kilgus, Gregor Langer, Kristina Duswald, Robert Zimmerleiter, Ivan Zorin, Thomas Berer, and Markus Brandstetter
Opt. Express 26(23) 30644-30654 (2018)
Yi Wang, Chuan Peng, HuanLin Zhang, and Han Q. Le
Opt. Express 12(21) 5243-5257 (2004)
Fartash Vasefi, Bozena Kaminska, Paulman K. Y. Chan, and Glenn H. Chapman
Opt. Express 16(19) 14456-14468 (2008)