Analysis of single unmodified proteins and their interactions with nanoaperture optical tweezers: PR65 case study

Elham Babaei; Samuel Mathew; Mirali Seyed Shariatdoust; Demelza Wright; Laura Itzhaki; Ivet Bahar; Shang-Hua Yang; Reuven Gordon

doi:10.1364/OMA.2023.AM3D.5

Biophotonics Congress: Optics in the Life Sciences 2023 (OMA, NTM, BODA, OMP, BRAIN)
Technical Digest Series (Optica Publishing Group, 2023),
paper AM3D.5
•https://doi.org/10.1364/OMA.2023.AM3D.5

Analysis of single unmodified proteins and their interactions with nanoaperture optical tweezers: PR65 case study

Elham Babaei, Samuel Mathew, Mirali Seyed Shariatdoust, Demelza Wright, Laura Itzhaki, Ivet Bahar, Shang-Hua Yang, and Reuven Gordon

Optical Manipulation and Its Applications 2023

Vancouver, British Columbia Canada
24–27 April 2023
ISBN: 978-1-957171-21-0

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Plasmonic and Thermophoretic Tweezers (AM3D)

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E. Babaei, S. Mathew, M. S. Shariatdoust, D. Wright, L. Itzhaki, I. Bahar, S. Yang, and R. Gordon, "Analysis of single unmodified proteins and their interactions with nanoaperture optical tweezers: PR65 case study," in Biophotonics Congress: Optics in the Life Sciences 2023 (OMA, NTM, BODA, OMP, BRAIN), Technical Digest Series (Optica Publishing Group, 2023), paper AM3D.5.

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Abstract

There is a new class of technologies emerging for observing unmodified proteins in action and at the single molecule level. This presentation will give an introduction to the double-nanohole nanoaperture optical tweezer approach and overview the developments from ours and other groups working in the area. Particularly, I will focus on the analysis of the A sub-unit of protein phosphatase PP2A: PR65.

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