Abstract
Photomultiplier tubes (PMTs) are the standard for high sensitivity detection of fluorescence signals, but are costly, fragile, have limited QE and worse sensitivity at far-red wavelengths. Newer detectors based on silicon photomultiplier (SiPM) technology can greatly improve sensitivity and imaging rates. The advantages and utilization of silicon photomultiplier technology for high sensitivity and high-speed imaging are reviewed.
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