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  • Biomedical Optical Spectroscopy and Diagnostics / Therapeutic Laser Applications
  • OSA Trends in Optics and Photonics Series (Optica Publishing Group, 1998),
  • paper TSuB5

Simultaneous Two-Photon Excitation of Photodynamic Therapy Agents

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Single-photon and two-photon excitation (TPE) of type I and II photosensitizers are examined. TPE is achieved using a mode-locked titanium:sapphire laser. In vitro and in vivo results support safe activation of PDT agents using non-resonant excitation in the near-infrared. TPE appears to offer finer treatment margins and may enable increased depth of penetration.

© 1998 Optical Society of America

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