Assessment of Preterm Birth Risk by Collagen Scoring with Polarized Light in Mice Model of Pregnancy

Hee Ryung Lee; Ilyas Saytashev; Vinh Nguyen Du Le; Mala Mahendroo; Jessica Ramella-Roman; Jessica Ramella-Roman; Tatiana Novikova; Tatiana Novikova

doi:10.1364/TRANSLATIONAL.2022.TM4B.4

Biophotonics Congress: Biomedical Optics 2022 (Translational, Microscopy, OCT, OTS, BRAIN)
Technical Digest Series (Optica Publishing Group, 2022),
paper TM4B.4
•https://doi.org/10.1364/TRANSLATIONAL.2022.TM4B.4

Assessment of Preterm Birth Risk by Collagen Scoring with Polarized Light in Mice Model of Pregnancy

Hee Ryung Lee, Ilyas Saytashev, Vinh Nguyen Du Le, Mala Mahendroo, Jessica Ramella-Roman, and Tatiana Novikova

Clinical and Translational Biophotonics 2022

Fort Lauderdale, Florida United States
24–27 April 2022
ISBN: 978-1-957171-03-6

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Women's Health (TM4B)

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H. R. Lee, I. Saytashev, V. N. D. Le, M. Mahendroo, J. Ramella-Roman, and T. Novikova, "Assessment of Preterm Birth Risk by Collagen Scoring with Polarized Light in Mice Model of Pregnancy," in Biophotonics Congress: Biomedical Optics 2022 (Translational, Microscopy, OCT, OTS, BRAIN), Technical Digest Series (Optica Publishing Group, 2022), paper TM4B.4.

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Abstract

Polarimetric images of thin histological sections of uterine cervices from non-pregnant and pregnant mice were recorded with Mueller matrix microscope. The results of two-Gaussian fit of the distributions of linear scalar retardance of cervical tissue demonstrated that imaging Mueller polarimetry may quantify the evolution of cervical collagen with pregnancy. It opens the avenue for a fast and non-contact polarimetric assessment of the preterm birth risk.

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