Abstract

A sandwich type titled fiber Bragg grating (TFBG) plasmonic sensor based on self-assembled p-mercaptophenylboronic acid (PMBA) monolayer and Au nanoparticles (AuNPs), has been demonstrated and successfully applied for sensitive and stable low-concentration glucose detection. The sensor was immobilized with PMBA monolayer acting as the highly sensitive and stable glucose recognition molecule instead of a traditional unstable enzyme. In the experiments, the high sensitivity for glucose detection is achieved, establishing a competitive limit of detection (LOD) of 295 pM and large dynamic measurement range from 1 nM to 10 mM simultaneously. Moreover, due to the unique two-set diol configurations of glucose, the combination of TFBG-SPR with AuNPs and PMBA exhibit a good selectivity over fructose and galactose, which both possess only one set of diol configurations. Non-invasive saliva glucose detection, as a better alternative to blood, has emerged and attracted many researchers’ attention. Therefore, the practicality of this method was successfully validated by detecting glucose in a simulated human saliva sample. We believe that this method represents an appealing solution for flexible, temperature-insensitive, high-sensitivity, and high-stability detection of ultra-low concentration glucose in modern non-invasive point-of-care testing as well as tumor micro-environment (TME) related cancer research.

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