Abstract

Gold-coated tilted fiber Bragg gratings (TFBGs) have been highly studied over the last years, mainly for biosensing purposes. They present a comb-like spectrum of narrow-band cladding mode resonances that is often demodulated by tracking the change of a selected peak. In this paper, we report a twentyfold more sensitive demodulation method based on the intersection of the upper and lower envelopes of gold-coated TFBG spectra. This method has been successfully applied in biosensing experiments towards the detection of HER2 (Human Epidermal Growth Factor Receptor-2) proteins, a relevant biomarker for breast cancer. Practical improvements have also been implemented. First, a uniform FBG has been superimposed on the TFBG to reduce the read-out wavelength span to 10 nm instead of 70 nm while keeping the temperature-compensated measurements. Second, a micro-fluidic system has been implemented to smoothly deliver the samples to the sensor. These 3 originalities make this sensing platform even more attractive for use in practical applications.

HER2 biosensing through SPR-envelope tracking in plasmonic optical fiber gratings

Maxime Lobry, Médéric Loyez, Karima Chah, Eman M. Hassan, Erik Goormaghtigh, Maria C. DeRosa, Ruddy Wattiez, and Christophe Caucheteur
Biomed. Opt. Express 11(9) 4862-4871 (2020)

Multimodal plasmonic optical fiber grating aptasensor

Maxime Lobry, Médéric Loyez, Eman M. Hassan, Karima Chah, Maria C. DeRosa, Erik Goormaghtigh, Ruddy Wattiez, and Christophe Caucheteur
Opt. Express 28(5) 7539-7551 (2020)

Plasmonic biosensing with tilted fiber Bragg gratings interrogated using a 512-pixel spectrometer

Maxime Lobry, Corentin Guyot, Damien Kinet, Karima Chah, and Christophe Caucheteur
Opt. Lett. 48(4) 976-979 (2023)

Phase interrogation of plasmonic tilted fiber Bragg grating biosensors through the Jones formalism

Hadrien Fasseaux, Médéric Loyez, Karima Chah, and Christophe Caucheteur
Opt. Express 30(19) 34287-34296 (2022)

Evaluation of gold layer configuration for plasmonic fiber grating biosensors

C. Caucheteur, M. Loyez, Á. González-Vila, and R. Wattiez
Opt. Express 26(18) 24154-24163 (2018)