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Computational refocusing in phase-unstable polarization-sensitive optical coherence tomography

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Abstract

We present computational refocusing in polarization-sensitive optical coherence tomography (PS-OCT) to improve spatial resolution in the calculated polarimetric parameters and extend the depth-of-field in phase-unstable, fiber-based PS-OCT systems. To achieve this, we successfully adapted short A-line range phase-stability adaptive optics (SHARP), a computational aberration correction technique compatible with phase-unstable systems, into a Stokes-based PS-OCT system with inter-A-line polarization modulation. Together with the spectral binning technique to mitigate system-induced chromatic polarization effects, we show that computational refocusing improves image quality in tissue polarimetry of swine eye anterior segment ex vivo with PS-OCT. The benefits, drawbacks, and potential applications of computational refocusing in anterior segment imaging are discussed.

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Supplementary Material (6)

NameDescription
Code 1       MATLAB implementation of the SHARP technique for polarization-sensitive optical coherence tomography
Supplement 1       Supplemental document with extended methods description
Visualization 1       Swine eye anterior segment imaging; Intensity en-face views comparison before and after computational refocusing in a phase-unstable polarization-sensitive optical coherence tomography system using the SHARP technique [described in "Computational ref
Visualization 2       PS-OCT SHARP Swine eye limbus: Intensity
Visualization 3       PS-OCT SHARP Swine eye limbus: DOP
Visualization 4       PS-OCT SHARP Swine eye limbus: Phase retardation

Data availability

Data underlying the results presented in this paper are not publicly available at this time but may be obtained from the authors upon reasonable request.

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