Abstract
A reflection-type phase-sensitive weak measurement for biosensing and chemical label-free sensing is presented. The phase difference between and polarizations in total internal reflection caused by biomolecular recognition is measured by weak value amplification. The system with and polarizations in a common path is stable and robust. The sensing process occurring on the silicon dioxide surface is achieved with a resolution of refractive index units. The applicability is demonstrated by real-time monitoring biomolecular interaction of IgG and protein A.
© 2016 Optical Society of America
Full Article | PDF ArticleMore Like This
Xiaodong Qiu, Linguo Xie, Xiong Liu, Lan Luo, Zhiyou Zhang, and Jinglei Du
Opt. Lett. 41(17) 4032-4035 (2016)
Yang Xu, Lixuan Shi, Tian Guan, Cuixia Guo, Dongmei Li, Yuxuan Yang, Xiangnan Wang, Luyuan Xie, Yonghong He, and Wenyue Xie
Opt. Express 26(16) 21119-21131 (2018)
Ana L. Hernández, Rafael Casquel, Miguel Holgado, Iñaki Cornago, Fátima Fernández, Paula Ciaurriz, Francisco J. Sanza, Beatriz Santamaría, María V. Maigler, and María Fe Laguna
Opt. Lett. 41(23) 5430-5433 (2016)