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NanoTracker: Force-Sensing Optical Tweezers for Quantitative Single-Molecule Nanomanipulation

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Abstract

In the past decade, experiments involving the manipulation and observation of nanostructures with light using optical tweezers methodology have developed from proof-of-principle experiments to an established quantitative technique in fields ranging from (bio)physics to cell biology. With optical tweezers, microscopically small objects can be held and manipulated. At the same time, the forces exerted on the trapped objects can be accurately measured.

© 2011 Optical Society of America

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