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Conferences > OMP > 2019 > OW4D > OW4D.4
  • Biophotonics Congress: Optics in the Life Sciences Congress 2019 (BODA,BRAIN,NTM,OMA,OMP)
  • OSA Technical Digest (Optica Publishing Group, 2019),
  • paper OW4D.4
  • •https://doi.org/10.1364/OMP.2019.OW4D.4

Long-Term Super-Resolution Imaging of Amyloid Structures Using Transient Binding of Thioflavin T

Kevin Spehar, Tianben Ding, Yuanzi Sun, Niraja Kedia, Jin Lu, George R. Nahass, Matthew D. Lew, and Jan Bieschke

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Abstract

Amyloids are implicated in Alzheimer’s disease but cannot be well resolved by standard light microscopy. We developed a tool to directly image native amyloid structures and dynamics at nanometer resolution over minutes to days.

© 2019 The Author(s)

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