Abstract

With experimental validation, an analytical exploration of a surface-plasmon-resonance- and evanescent-wave-based fiber optic biosensor, using Bessel–Gauss beams for early detection of breast cancer, is proposed and designed here. The observed sensitivity is 0.58 nm/ng/mL and 11,928.25 dB/RIU with a resolution of ${8.38} \times {{10}^{- 7}}$, which is 10 times better than the reported ray-theory-based articles reported to date using a Gaussian beam. To analyze more effectively the higher-order modes and to achieve more similarity between the analytical and experimental solutions, the wave-theory-based approach is adopted here. With this approach, for the first time to our knowledge using a Bessel–Gauss beam, higher sensitivity is achieved for fiber optic breast cancer detection. The enhanced sensitivity at lower concentrations of the Human Epidermal Growth Factor Receptor 2 biomarker has conceptualized the idea of early detection of breast cancer by optically quantifying the earlier stage of cancer.

© 2021 Optical Society of America

Wave-theory-based analysis of a fiber optic bio-sensor illuminated by radially polarized Bessel–Gauss beam: an approach for early diagnosis of breast cancer with a high-resolution wavelength-interrogation technique

Bijaya Saha, Nabamita Goswami, and Ardhendu Saha
Appl. Opt. 61(35) 10408-10417 (2022)

Proposal for the detection of breast cancer at its early stage using wave-theory-based analysis in a tapered fiber structure illuminated by the Bessel–Gauss beam for enhanced sensitivity

Bijaya Saha, Nabamita Goswami, and Ardhendu Saha
J. Opt. Soc. Am. B 40(3) 574-584 (2023)

Investigation of a multimode interference-based high-sensitivity refractive index sensor realized by shining a zero-order Bessel–Gauss beam

Arijit Datta and Ardhendu Saha
J. Opt. Soc. Am. B 34(7) 1327-1339 (2017)

Label-free detection of breast cancer cells using a functionalized tilted fiber grating

Xiaoyong Chen, Pin Xu, Wenwei Lin, Jin Jiang, Hang Qu, Xuehao Hu, Jinghua Sun, and Yukun Cui
Biomed. Opt. Express 13(4) 2117-2129 (2022)

Surface plasmon biosensor based on Bi₂Te₃ antimonene heterostructure for the detection of cancer cells

Arun Uniyal, Brajlata Chauhan, Amrindra Pal, and Yadvendra Singh
Appl. Opt. 61(13) 3711-3719 (2022)