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Highly sensitive surface-plasmon-resonance-based fiber optic breast cancer detection by shining a Bessel–Gauss beam: a wave-theory-based approach

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Abstract

With experimental validation, an analytical exploration of a surface-plasmon-resonance- and evanescent-wave-based fiber optic biosensor, using Bessel–Gauss beams for early detection of breast cancer, is proposed and designed here. The observed sensitivity is 0.58 nm/ng/mL and 11,928.25 dB/RIU with a resolution of ${8.38} \times {{10}^{- 7}}$, which is 10 times better than the reported ray-theory-based articles reported to date using a Gaussian beam. To analyze more effectively the higher-order modes and to achieve more similarity between the analytical and experimental solutions, the wave-theory-based approach is adopted here. With this approach, for the first time to our knowledge using a Bessel–Gauss beam, higher sensitivity is achieved for fiber optic breast cancer detection. The enhanced sensitivity at lower concentrations of the Human Epidermal Growth Factor Receptor 2 biomarker has conceptualized the idea of early detection of breast cancer by optically quantifying the earlier stage of cancer.

© 2021 Optical Society of America

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