Abstract

Osteoporosis is a progressive bone disease, which is characterized by a decrease in the bone mass and deterioration in bone micro-architecture. In theory, photoacoustic (PA) analysis has the potential to obtain the characteristics of the bone effectively. In this study, we try to compare the PA spectral analysis (PASA) method with the quantitative ultrasound (QUS) method in osteoporosis assessment. We compare the quantified parameter slope from the PASA and broadband ultrasound attenuation from QUS among different bone models, respectively. Both the simulation and ex vivo experiment results show that bone with lower bone mineral density has the higher slope in the PASA method. Our comparison study proves that the PASA method has the same efficiency as QUS in osteoporosis assessment.

© 2017 Chinese Laser Press

Characterization of bone microstructure using photoacoustic spectrum analysis

Ting Feng, Joseph E. Perosky, Kenneth M. Kozloff, Guan Xu, Qian Cheng, Sidan Du, Jie Yuan, Cheri X. Deng, and Xueding Wang
Opt. Express 23(19) 25217-25224 (2015)

Photoacoustic characterization of bone physico-chemical information

Weiya Xie, Ting Feng, Dong Yu, Dean Ta, Liming Cheng, and Qian Cheng
Biomed. Opt. Express 13(5) 2668-2681 (2022)

Interstitial photoacoustic spectral analysis: instrumentation and validation

Haonan Zhang, Wan-yu Chao, Qian Cheng, Shengsong Huang, Xueding Wang, Denglong Wu, and Guan Xu
Biomed. Opt. Express 8(3) 1689-1697 (2017)

Quantifying Gleason scores with photoacoustic spectral analysis: feasibility study with human tissues

Guan Xu, Mandy C. Davis, Javed Siddiqui, Scott A. Tomlins, Shengsong Huang, Lakshmi P. Kunju, John T. Wei, and Xueding Wang
Biomed. Opt. Express 6(12) 4781-4789 (2015)

Ultrasound-modulated light tomography assessment of osteoporosis

A. Lev, E. Rubanov, B. Sfez, S. Shany, and A. J. Foldes
Opt. Lett. 30(13) 1692-1694 (2005)